The online supplement provides the complete analytical outputs from all stages of the study, organized into nine chapters that can be navigated via the Table of Contents on the left. Each chapter corresponds to a major component of the analysis workflow:
test 4
| Control (N=73) |
BEP/BEP (N=66) |
BEP/IFA (N=56) |
IFA/BEP (N=81) |
Overall (N=276) |
|
|---|---|---|---|---|---|
| sex | |||||
| Female | 38 (52.1%) | 29 (43.9%) | 26 (46.4%) | 46 (56.8%) | 139 (50.4%) |
| Male | 35 (47.9%) | 37 (56.1%) | 30 (53.6%) | 35 (43.2%) | 137 (49.6%) |
| mage | |||||
| Mean (SD) | 25.0 (5.28) | 23.4 (5.57) | 24.6 (5.56) | 23.6 (5.83) | 24.1 (5.58) |
| Median [Min, Max] | 24.0 [17.0, 39.0] | 22.5 [16.0, 36.0] | 23.0 [16.0, 40.0] | 23.0 [15.0, 39.0] | 23.0 [15.0, 40.0] |
| meducyrs | |||||
| Mean (SD) | 2.66 (3.38) | 2.36 (3.34) | 3.07 (3.60) | 3.79 (3.95) | 3.00 (3.62) |
| Median [Min, Max] | 2.00 [0, 10.0] | 2.00 [0, 10.0] | 2.00 [0, 10.0] | 2.00 [0, 13.0] | 2.00 [0, 13.0] |
| mhtcm | |||||
| Mean (SD) | 162 (6.68) | 162 (5.05) | 164 (6.02) | 162 (5.35) | 162 (5.82) |
| Median [Min, Max] | 162 [142, 174] | 162 [150, 174] | 163 [151, 178] | 162 [149, 173] | 162 [142, 178] |
| parity | |||||
| Mean (SD) | 2.99 (1.72) | 2.83 (1.71) | 2.95 (1.67) | 2.80 (1.76) | 2.89 (1.71) |
| Median [Min, Max] | 3.00 [1.00, 8.00] | 3.00 [1.00, 7.00] | 3.00 [1.00, 7.00] | 2.00 [1.00, 8.00] | 3.00 [1.00, 8.00] |
| nperson | |||||
| Mean (SD) | 5.92 (4.02) | 6.62 (5.22) | 6.88 (4.05) | 6.21 (5.00) | 6.37 (4.62) |
| Median [Min, Max] | 5.00 [2.00, 23.0] | 5.00 [2.00, 27.0] | 6.00 [2.00, 20.0] | 4.00 [2.00, 30.0] | 5.00 [2.00, 30.0] |
| nrooms | |||||
| Mean (SD) | 2.37 (1.98) | 2.50 (1.68) | 2.46 (1.25) | 2.37 (1.56) | 2.42 (1.65) |
| Median [Min, Max] | 2.00 [1.00, 12.0] | 2.00 [1.00, 9.00] | 2.00 [1.00, 6.00] | 2.00 [1.00, 9.00] | 2.00 [1.00, 12.0] |
| imp_water_src | |||||
| Improved | 41 (56.2%) | 36 (54.5%) | 32 (57.1%) | 53 (65.4%) | 162 (58.7%) |
| Unimproved | 32 (43.8%) | 30 (45.5%) | 24 (42.9%) | 28 (34.6%) | 114 (41.3%) |
| impfloor | |||||
| 0 | 31 (42.5%) | 25 (37.9%) | 23 (41.1%) | 32 (39.5%) | 111 (40.2%) |
| 1 | 42 (57.5%) | 41 (62.1%) | 33 (58.9%) | 49 (60.5%) | 165 (59.8%) |
| missing | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| cookplac | |||||
| 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | |
| missing | 73 (100%) | 66 (100%) | 56 (100%) | 81 (100%) | 276 (100%) |
| No | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Separate space for cooking | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Yes | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| dvseason | |||||
| Early Summer | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Late Summer / Monsoon | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Post-Harvest | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Post monsoon / Autumn | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Pre-Harvest | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Rainy Season | 56 (76.7%) | 56 (84.8%) | 47 (83.9%) | 63 (77.8%) | 222 (80.4%) |
| Summer Season | 17 (23.3%) | 10 (15.2%) | 9 (16.1%) | 18 (22.2%) | 54 (19.6%) |
| Winter | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| dlvloc | |||||
| 0 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| 1 | 3 (4.1%) | 1 (1.5%) | 1 (1.8%) | 2 (2.5%) | 7 (2.5%) |
| 3 | 67 (91.8%) | 61 (92.4%) | 52 (92.9%) | 72 (88.9%) | 252 (91.3%) |
| 4 | 3 (4.1%) | 4 (6.1%) | 3 (5.4%) | 7 (8.6%) | 17 (6.2%) |
| 5 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| hhwealth | |||||
| Mean (SD) | -0.0952 (0.987) | 0.0108 (0.933) | 0.250 (1.03) | -0.161 (1.03) | -0.0190 (1.00) |
| Median [Min, Max] | -0.134 [-2.26, 3.04] | 0.109 [-1.77, 1.86] | 0.216 [-2.04, 2.34] | -0.298 [-2.05, 2.64] | -0.00526 [-2.26, 3.04] |
| hhfoodsecure | |||||
| Mean (SD) | 3.03 (3.20) | 3.17 (2.82) | 3.02 (2.86) | 3.90 (3.93) | 3.32 (3.29) |
| Median [Min, Max] | 2.00 [0, 14.0] | 3.00 [0, 11.0] | 3.00 [0, 12.0] | 4.00 [0, 14.0] | 3.00 [0, 14.0] |
| Control (N=50) |
BEP+ExBf (N=50) |
BEP+ExBf+AZT (N=50) |
Overall (N=150) |
|
|---|---|---|---|---|
| sex | ||||
| Female | 29 (58.0%) | 24 (48.0%) | 31 (62.0%) | 84 (56.0%) |
| Male | 21 (42.0%) | 26 (52.0%) | 19 (38.0%) | 66 (44.0%) |
| mage | ||||
| Mean (SD) | 24.0 (4.77) | 25.2 (5.97) | 23.4 (3.66) | 24.2 (4.92) |
| Median [Min, Max] | 23.0 [17.0, 35.0] | 25.0 [17.0, 37.0] | 24.0 [16.0, 35.0] | 24.0 [16.0, 37.0] |
| meducyrs | ||||
| Mean (SD) | 7.46 (2.05) | 7.96 (1.93) | 8.26 (1.79) | 7.89 (1.94) |
| Median [Min, Max] | 8.00 [2.00, 14.0] | 8.00 [3.00, 12.0] | 8.00 [3.00, 14.0] | 8.00 [2.00, 14.0] |
| mhtcm | ||||
| Mean (SD) | 153 (5.27) | 151 (5.73) | 153 (6.35) | 152 (5.80) |
| Median [Min, Max] | 153 [143, 165] | 151 [142, 165] | 153 [139, 168] | 153 [139, 168] |
| parity | ||||
| Mean (SD) | 2.68 (1.78) | 3.10 (2.38) | 2.42 (1.36) | 2.73 (1.89) |
| Median [Min, Max] | 2.00 [1.00, 8.00] | 3.00 [1.00, 12.0] | 2.00 [1.00, 6.00] | 2.00 [1.00, 12.0] |
| nperson | ||||
| Mean (SD) | 10.2 (3.64) | 9.58 (4.44) | 10.3 (4.57) | 10.0 (4.22) |
| Median [Min, Max] | 10.0 [3.00, 19.0] | 9.00 [3.00, 19.0] | 10.5 [3.00, 18.0] | 10.0 [3.00, 19.0] |
| nrooms | ||||
| Mean (SD) | 2.74 (1.29) | 2.46 (1.51) | 2.58 (1.54) | 2.59 (1.45) |
| Median [Min, Max] | 3.00 [1.00, 6.00] | 2.00 [1.00, 7.00] | 2.00 [1.00, 6.00] | 2.00 [1.00, 7.00] |
| imp_water_src | ||||
| Improved | 48 (96.0%) | 47 (94.0%) | 48 (96.0%) | 143 (95.3%) |
| Unimproved | 2 (4.0%) | 3 (6.0%) | 2 (4.0%) | 7 (4.7%) |
| impfloor | ||||
| 0 | 1 (2.0%) | 1 (2.0%) | 2 (4.0%) | 4 (2.7%) |
| 1 | 49 (98.0%) | 49 (98.0%) | 48 (96.0%) | 146 (97.3%) |
| missing | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| cookplac | ||||
| 1 (2.0%) | 4 (8.0%) | 3 (6.0%) | 8 (5.3%) | |
| missing | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| No | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Separate space for cooking | 49 (98.0%) | 46 (92.0%) | 47 (94.0%) | 142 (94.7%) |
| Yes | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| dvseason | ||||
| Early Summer | 4 (8.0%) | 3 (6.0%) | 7 (14.0%) | 14 (9.3%) |
| Late Summer / Monsoon | 15 (30.0%) | 14 (28.0%) | 16 (32.0%) | 45 (30.0%) |
| Post-Harvest | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Post monsoon / Autumn | 22 (44.0%) | 19 (38.0%) | 13 (26.0%) | 54 (36.0%) |
| Pre-Harvest | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Rainy Season | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Summer Season | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Winter | 9 (18.0%) | 14 (28.0%) | 14 (28.0%) | 37 (24.7%) |
| dlvloc | ||||
| 0 | 13 (26.0%) | 10 (20.0%) | 16 (32.0%) | 39 (26.0%) |
| 1 | 3 (6.0%) | 5 (10.0%) | 5 (10.0%) | 13 (8.7%) |
| 3 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| 4 | 32 (64.0%) | 33 (66.0%) | 27 (54.0%) | 92 (61.3%) |
| 5 | 2 (4.0%) | 2 (4.0%) | 2 (4.0%) | 6 (4.0%) |
| hhwealth | ||||
| Mean (SD) | 0.0389 (0.862) | -0.0987 (1.05) | 0.0598 (1.09) | 0.000000000000000137 (1.00) |
| Median [Min, Max] | 0.0158 [-1.68, 2.09] | -0.246 [-1.68, 2.13] | 0.0942 [-1.68, 1.94] | -0.0227 [-1.68, 2.13] |
| hhfoodsecure | ||||
| Mean (SD) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Median [Min, Max] | 0 [0, 0] | 0 [0, 0] | 0 [0, 0] | 0 [0, 0] |
| Control (N=54) |
Az. (N=45) |
Nico (N=48) |
Nico+Az. (N=53) |
Overall (N=200) |
|
|---|---|---|---|---|---|
| sex | |||||
| Female | 26 (48.1%) | 18 (40.0%) | 28 (58.3%) | 29 (54.7%) | 101 (50.5%) |
| Male | 28 (51.9%) | 27 (60.0%) | 20 (41.7%) | 24 (45.3%) | 99 (49.5%) |
| mage | |||||
| Mean (SD) | 30.8 (7.76) | 28.5 (7.01) | 28.4 (7.00) | 29.5 (6.66) | 29.4 (7.14) |
| Median [Min, Max] | 31.0 [19.0, 42.0] | 26.0 [18.0, 42.0] | 27.0 [19.0, 46.0] | 29.0 [18.0, 46.0] | 28.0 [18.0, 46.0] |
| meducyrs | |||||
| Mean (SD) | 6.85 (2.59) | 6.38 (2.61) | 6.77 (2.43) | 6.19 (2.98) | 6.55 (2.67) |
| Median [Min, Max] | 7.00 [0, 13.0] | 7.00 [0, 12.0] | 7.00 [0, 11.0] | 7.00 [0, 13.0] | 7.00 [0, 13.0] |
| mhtcm | |||||
| Mean (SD) | 158 (5.34) | 157 (4.22) | 158 (5.74) | 158 (6.29) | 158 (5.48) |
| Median [Min, Max] | 159 [144, 168] | 157 [145, 166] | 158 [148, 172] | 158 [143, 178] | 158 [143, 178] |
| parity | |||||
| Mean (SD) | 4.89 (2.83) | 3.98 (2.55) | 3.92 (2.57) | 4.55 (2.58) | 4.36 (2.65) |
| Median [Min, Max] | 5.00 [1.00, 12.0] | 3.00 [1.00, 12.0] | 3.00 [1.00, 9.00] | 5.00 [1.00, 12.0] | 4.00 [1.00, 12.0] |
| nperson | |||||
| Mean (SD) | 7.52 (2.49) | 7.24 (2.89) | 6.81 (2.88) | 7.45 (2.61) | 7.27 (2.70) |
| Median [Min, Max] | 7.00 [3.00, 14.0] | 7.00 [3.00, 14.0] | 7.00 [1.00, 18.0] | 8.00 [3.00, 14.0] | 7.00 [1.00, 18.0] |
| nrooms | |||||
| Mean (SD) | 4.87 (2.18) | 4.58 (2.26) | 4.48 (2.13) | 4.91 (2.26) | 4.72 (2.20) |
| Median [Min, Max] | 4.00 [1.00, 11.0] | 4.00 [1.00, 12.0] | 4.00 [2.00, 11.0] | 5.00 [2.00, 12.0] | 4.00 [1.00, 12.0] |
| imp_water_src | |||||
| Improved | 37 (68.5%) | 30 (66.7%) | 32 (66.7%) | 32 (60.4%) | 131 (65.5%) |
| Unimproved | 17 (31.5%) | 15 (33.3%) | 16 (33.3%) | 21 (39.6%) | 69 (34.5%) |
| impfloor | |||||
| 0 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| 1 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| missing | 54 (100%) | 45 (100%) | 48 (100%) | 53 (100%) | 200 (100%) |
| cookplac | |||||
| 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | |
| missing | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| No | 18 (33.3%) | 16 (35.6%) | 21 (43.8%) | 21 (39.6%) | 76 (38.0%) |
| Separate space for cooking | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Yes | 36 (66.7%) | 29 (64.4%) | 27 (56.3%) | 32 (60.4%) | 124 (62.0%) |
| dvseason | |||||
| Early Summer | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Late Summer / Monsoon | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Post-Harvest | 30 (55.6%) | 30 (66.7%) | 28 (58.3%) | 33 (62.3%) | 121 (60.5%) |
| Post monsoon / Autumn | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Pre-Harvest | 24 (44.4%) | 15 (33.3%) | 20 (41.7%) | 20 (37.7%) | 79 (39.5%) |
| Rainy Season | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Summer Season | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Winter | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| dlvloc | |||||
| 0 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| 1 | 20 (37.0%) | 22 (48.9%) | 22 (45.8%) | 29 (54.7%) | 93 (46.5%) |
| 3 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| 4 | 34 (63.0%) | 23 (51.1%) | 26 (54.2%) | 24 (45.3%) | 107 (53.5%) |
| 5 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| hhwealth | |||||
| Mean (SD) | -0.261 (0.611) | 0.168 (1.13) | -0.0165 (1.08) | 0.139 (1.09) | 0.0000000000000000897 (1.00) |
| Median [Min, Max] | -0.360 [-0.807, 2.32] | -0.137 [-0.807, 5.66] | -0.360 [-0.807, 5.66] | -0.360 [-0.851, 3.43] | -0.360 [-0.851, 5.66] |
| hhfoodsecure | |||||
| Mean (SD) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Median [Min, Max] | 0 [0, 0] | 0 [0, 0] | 0 [0, 0] | 0 [0, 0] | 0 [0, 0] |
For each milk modality, the intervention effects are shown in forest plots, faceted by study and visit. Significant effects after FDR correction are shown with solid circles. Intervention average treatment effects are first shown for combined intervention arms (pooling post-natal nutritional intervention arms), and then the effects are shown contrasting each randomized arm against the control arms. Effects are estimated using TMLE, adjusting for baseline prognistic factors. Tables of results are shown below each forest plot, which also include unscaled estimates (in original units of measurement).


Includes fat-soluble vitamins








For each milk modality, the intervention effects are shown in forest plots, faceted by study and visit. Significant effects after FDR correction are shown with solid circles. Intervention average treatment effects are first shown for combined intervention arms (pooling post-natal nutritional intervention arms), and then the effects are shown contrasting each randomized arm against the control arms. Effects are estimated using TMLE, unadjusted for baseline prognistic factors.










Intervention effects on microbiome diversity measures
Combined arms:

Stratified arms:

Intervention effects on individual microbiome components
Combined arms:

Stratified arms:

Note- proteomics were taken in a subset of mother-child dyads, and was only taken in the control arm of the Elicit trial, and so intervention effects were not estimatable.
No specific pattern of effects was noted, and the proportion of significant was consisten with false postives under a global null hypothesis.





-below the 10th percentile -note sparse estimates -TMLE estimates -add citations -add tabulation of cutoffs (including sparse)

(Add figure legend)

## Adding missing grouping variables: `measure`

## Adding missing grouping variables: `measure`

## Adding missing grouping variables: `measure`

## Adding missing grouping variables: `measure`

## Adding missing grouping variables: `measure`

## Adding missing grouping variables: `measure`



## Warning in instance$preRenderHook(instance): It seems your data is too big for client-side DataTables. You
## may consider server-side processing: https://rstudio.github.io/DT/server.html
## Warning in instance$preRenderHook(instance): It seems your data is too big for client-side DataTables. You
## may consider server-side processing: https://rstudio.github.io/DT/server.html
## $p_misame_scaled

##
## $p_elicit_scaled

##
## $p_vital_scaled

##
## $p_misame_unscaled

##
## $p_misame_unscaled

##
## $p_vital_unscaled
